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People overview
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Research Interest Top
Research activities can be summarized as follows:
Detailed studies of the mechanical and electrophysiological function of mouse hearts. The Bioengineering / Computational Biology elements of my research program have also continued to progress. Our published model of human atrial electrophysiological activity has been augmented so that it can be more useful as an education resource, and as a tool for Phase II compound screening / drug discovery. Progress continues in novel studies of the paracrine effects of an atrial natriuretic peptide, CNP, on the electrical and mechanical activity of the heart. The Dr. W.H. Dillmann laboratorium at the University of California at San Diego continues to be a valuable collaboration and resource in our projects on thyroid hormone effects on cardiac electrical and mechanical activity in mouse and rat models. Awards and Editorial Boards Top
Awards
American Heart Association Established Investigators Award (1982-1985)Heart and Stroke Foundation of Alberta Endowed Chair (1995-2003) Editorial Board Memberships:
Journal of General Physiology (1983-1988)American Journal of Physiology (1987-1993) Journal of Physiology (1987-1994) Circulation Research (1994-present) Editorial Appointments:
American Journal of Physiology (Heart and Circulation), Associate Editor, 1990-1993Selected Publications Top
Demir, S.S., Clark, J.W. and Giles, W.R. (1998). Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit heart: a unifying model. Am. J. Physiol. 276: H2221-H2244, 1999.
Larsen, T.S., Dani, R., Severson, D.L., Giles, W.R., Lopaschuk, G.D., Belke D., and Tyberg, J.V. Response of the isolated working mouse heart to changes in preload and heart rate. Pflugers Archiv. 437: 979-985, 1999.
Poon, B.Y., Ward, C.A., Giles, W.R. and Kubes, P. (1998) Emigrated neutrophils regulate ventricular contractility via α4-integrin. Circ Res 84: 1245-1251, 1999.
Minamisawa, S., et al. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. CELL 99: 313-322, 1999.
Nguyen-Tran V.T.B., et al. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages. CELL 102: 671-682, 2000.
Nygren, A., Clark, R.B., Belke, D., Kondo, C., Giles, W.R. and Witkowski, F.X. Voltage-sensitive dye mapping of activation and conduction in adult mouse hearts. Annals of Biomedical Engineering 28: 958-967, 2000.
Poon, B.Y., Ward, C.A., Cooper, C.B., Giles, W.R., Burns, A.R., and Kubes, P. α4-Integrin mediates neutrophil-induced free radical injury to cardiac myocytes. J. Cell Biol. 152: 857-866, 2001.
Cordeiro, J.M., Spitzer, K.W., Giles, W.R., Ershler, P.E., Cannell, M.B. and Bridge, J.H.B. Location of the initiation site of Ca2+ transients and spikes in rabbit heart Purkinje cells. J. Physiol. 531: 301-314, 2001.
Pandit, S.V., Clark, R.B., Giles, W.R. and Demir, S.S. A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes. Biophys. J. 81(6): 3029-3051, 2001.
Kuo, H.-C., et al. A defect in the Kv channel accessory protein 2 (KChIP2) gene leads to a complete loss of the transient outward potassium current (Ito) and confers genetic susceptibility to ventricular tachycardia. CELL 107: 1-20, 2001.
Pandit, S.V., Giles, W.R. and Demir, S.S. A mathematical model of the electrophysiological alterations of rat ventricular myocytes in Type-I diabetes. Biophys J 84:832-841, 2003
Nygren, A., Kondo, C., Clark, R.B. and Giles W.R. Voltage-sensitive dye mapping the Langendorff-perfused rat heart. Am J Physiol 284:H892-H203, 2003.
Baczko, I., Giles, W.R. and Light, P.E. Resting membrane potential regulates Na+-Ca2+ exchange-mediated Ca2+ overload during hypoxia/reoxygenation in rat ventricle. J Physiol 550: 889-898, 2003.
Clark, R.B., Mongoni, M.E., Leuger, A., Nargeot, J. and Giles, W.R. A rapidly-activated delayed rectifier K+ current, IKr regulates pacemaker activity in adult mouse sinoatrial node cells. Am J Physiol 279: 5450- 5459, 2004.
Hatano, N., Ohya, S.G., Muraki, K., Clark, R.B., Giles, W.R. and Imaizumi, Y. Two arginines in C-terminus domain are essential for the voltage-dependent regulation of A-type K+ current through Kv 4 channel subfamily. J Biol Chem 279: 5450-5459, 2004.
Baczko, I., Giles, W.R. and Light, P.E. Pharmacological activation of plasma membrane KATP channels reduces reoxygenation-induced Ca2+ overload in cardiac myocytes via modulation of the diastolic membrane potential. Brit. J. Pharm. 141: 1059-1067, 2004.
Rose, R.A., Lomax, A.E., Condo, C.S., Anand-Srivastava, M.B. and Giles, W.R. Effects of C-type natriuretic peptide on ionic currents in mouse sino atrial node: A role for the NPR-C receptor. Am. J. Physiol. 286: H1970-H1977, 2004.
Pashmforoush, M., et al., A post-natal NKx2.5 pathway in conduction system myocytes drives atrioventricular node maturation and is defective in a subset of human cardiac arrhythmias and associated sudden death CELL, 117: 373-386, 2004.
Bouchard, R., Clark, R.B., Juhasz, A.E. and Giles, W.R. Changes in extracellular K+ concentration modulate contractility of rat and rabbit cardiac myocytes via the inward rectifier K+ current IK1. J. Physiol 556.3: 773-790, 2004.
Nygren, A., Lomax, A.E. and Giles, W.R. Heterogeneity of action potential durations in isolated mouse left and right atria recorded using voltage-sensitive dye mapping. Am. J. Physiol, 187: H110-H117, 2004.
Operating Funds Top
CIHR, Cardiovascular effects of C-type natriuretic peptides (2001-2006)
CIHR, Ionic basis of ventricular inflammation neutrophil / myocyte interaction (2001-2006) NIH (co-investigator Dr. W. Dillmann), Molecular aspects of thyroid hormone-induced modulation of cardiac myocytes (2003-07) NIH (co-investigator Dr. W. Dillmann), Diabetic cardiomyopathy and calcium flux (2004-2009) |
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Feb 18th, 2005 |
