Genomics and Systems Biotechnology Laboratory

 

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Publications
Barbee, K.D.; Huang, X. Magnetic Assembly of High-Density DNA Arrays for Genomics Analyses. Analytical Chemistry (2008) DOI: 10.1021/ac702192y. (ABSTRACT)
Bulyk, M.L.; Huang, X.; Choo, Y.; Church, G.M.  Exploring the DNA-Binding Specificities of Zinc Fingers with DNA Microarrays. Proc. Natl. Acad. Sci. U.S.A. 2001 Jun 12; 98 (13). (ABSTRACT)
Zhong, X.; Lizardi, P.M.; Huang, X.; Bray-Ward, P.; Ward, D.C. Visualization of Oligonucleotide Probes and Point Mutations in Interphase Nuclei and DNA Fibers Using Rolling Circle DNA Amplification. Proc. Natl. Acad. Sci. U.S.A. (2001) 98:3940-3945. (ABSTRACT)
Ozcan,T., Burki, N., Parkash, V., Huang, X., Pejovic, T., Mahoney, M.J., Mari, G. and Ward, D.C. Cytogenetical Diagnosis in Paraffin-embedded Fetoplacental Tissue Using Comparative Genomic Hybridization. Prenatal Diagnosis, 20(1):41-44 (2000). (ABSTRACT)
Lizardi, P.M.; Huang, X.; Zhu, Z.; Bray-Ward, P.; Thomas, D.C.; Ward, D.C. Mutation detection and single molecule counting using isothermal rolling circle amplification. Nature Genetics (1998) 19:225-232. (ABSTRACT)
Huang, X.; Boxer, S.G. Discovery of New Ligand Binding Pathways in Myoglobin by Random Mutagenesis. Nature Structural Biology, 1(4): 226-229 (1994). (ABSTRACT)
 
Patents
Barbee, K.D.; Huang, X. Methods and Devices for Biomolecular Arrays. Application No. 60/887,244 (2007).
Lizardi, P.M.; Huang, X. Single Molecule Analysis Target-Mediated Ligation of Bipartite Primers. Patent No. 6,316,229 (2001) (Full PDF)
 
Funding
Genome Sequencing by Ligation Using Nano-Arrays of Single DNA Molecules (NIH/NHGRI 1 R21 R21HG04130) (ABSTRACT)
Career Award (NSF BES-0547193)
Massively Parallel Cloning and Sequencing of DNA (NIH/HNGRI 5 R21 R21HG03587) (ABSTRACT)

 

 

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