Selected Recent Publications

1. Flaim, C..J.; Teng, D.; Chien, S., and Bhatia, S.N.: Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells and Development, in press, 2007.

2. Chiu, J.-J.; Chen, L.J.; Lee, C.L.; Lee, P.-L.; Lee, D.Y.; Tsai, M.C.; Lin, C.W.; Usami, S., and Chien, S.:  Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. Blood 110:519-528, 2007 Mar 21; [Epub ahead of print]. PMID: 17371946.

3. D’Lima, D.D.; Patil, S.; Steklov, N.; Chien, S., and Colwell, C.W. Jr.: In vivo knee moments and shear after total knee arthroplasty. J. Biomech., in press, PMID:17462659, 2007.

4. Wang, Y.X.; Chang, J.; Chen, K.D.; Li, S.; Li, Y.S.J.; Wu, C., and Chien. S.: Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress. Proc Natl Acad Sci U S A., in press, 2007.

5. Qin, X.; Tian, J.; Zhang, P.; Fan, Y.; Chen, L.; Guan, Y.; Fu, Y.; Zhu., Y.; Chien, S., and Wang, N.: Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovasc Res. 74:506-514, 2007 Feb 20; [Epub ahead of print]. PMID: 17368438.

6. Hu, Y.L., and Chien, S.: Dynamic motion of paxillin on actin filaments in living endothelial cells. Biochem. Biophys. Res. Commun. 357:871-876, 2007. PMID:17466945.

7. Mitchell, B.; Jacobs, R.; Li, J.; Chien, S., and Kintner, C.: A positive feedback mechanism governs the polarity and motion of motile cilia.  Nature 447:97-101, 2007. PMID 17450123.

8. Wu, C.C.; Li, Y.S.J.; Haga, J.H.; Kaunas, R.; Chiu, J.J.; Su, F.C.; Usami, S., and Chien, S.: Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry. Proc Natl Acad Sci U S A. 104:1254-1259, 2007. PMID:17229844.

9. Chien, S.: Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell. Am. J. Physiology: Heart and Circulatory Physiology, 292:H1209-1224, 2007. PMID:17098825.

10. Zeng, Z.; Xu, X.; Zhang, Y.; Xing, J., Long, J.; Gu, L.; Wang, X.; Sun, D.; Ka, W.; Yao, W.; Wen, Z., and Chien, S.: Tumor-derived factors impaired motility and immune functions of dendritic cells through derangement of biophysical characteristics and reorganization of cytoskeleton. Cell Motil Cytoskeleton. 64:186-198, 2007. PMID:17183544.

11. Haga, J.H.; Li, Y.S.J., and Chien, S.: Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells. J. Biomech. 40:947-960, 2006. PMID:16867303.

12. Guo, D.; Chien, S., and Shyy, J.Y.J.: Regulation of endothelial cell cycle by laminar versus oscillatory flow.  Distinct modes of interactions of AMP-activated protein knase and Akt pathways. Circulation Res. 100:564-571, 2007. PMID: 17272808.

13. Lorenzen-Schmidt, I.; Schmid-Schoenbein, G.W.; Giles, W.R.; McCulloch, A.D.; Chien, S., and Omens, J.H.: Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear.  Cell Biochem Biophys. 46:113-122, 2006. PMID:17012753.

14. Kaunas, R.; Usami, S., and Chien, S.: Regulation of Stretch-induced JNK Activation by Stress Fiber Orientation. Cellular Signaling, 18:1924-1931, 2006. PMID:16581230.

15. Hu, Y.L.; Haga, J.H.; Miao, H.; Wang, Y.; Li, Y.S., and Chien, S.: Roles of microfilaments and microtubules in paxillin dynamics. Biochem. Biophys. Res. Commun., 348:14631471, 2006.

16. Zeng, Z.; Liu, X.; Jiang, Y.; Wang, G.; Zhan, J.; Guo, J.; Yao, W.; Sun, D.; Ka, W.; Tang, Y.; Tang, J.; Wen, Z., and Chien, S.: Biophysical studies on the differentiation of human CD14+ monocytes into dendritic cells. Cell Biochem Biophys. 45:19-30, 2006.

17. Hornberger, T.A.; Sukhija, K.B., and Chien S. : Regulation of mTOR by Mechanically induced signaling events in skeletal muscle.  Cell Cycle, 5:1391-1396, 2006.

18. Hornberger, T.A.; Chu W.K.; Mak Y.W.; Hsiung J.W.; Huang S.A. and Chien S. : The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc. Nat. Acad. Sci., USA, 103:4741-4746, 2006.

19. Chen, C.N.; Chang, S.F.; Lee, P.L.; Chang, K.; Chen, L.J.; Usami, S.; Chien, S., and Chiu, J.J.: Neutrophils, lymphocytes, and monocytes exhibit diverse behaviors in transendothelial and subendothelial migrations under co-culture with smooth muscle cells in disturbed flow.  Blood, 107:1933-1942, 2006.

20. Wu, C.C.; Li, Y.S.J.; Haga, J.H.; Wang, N.; Lian, L.Y.Z.; Su, F.C.; Usami, S., and Chien, S.: R­oles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow. J. Cell. Biochem., 98:632-641, 2006.

21. Chien, S.: Molecular basis of rheological modulation of endothelial functions: Importance of stress direction. Poiseuille Award Lecture. Biorheology, 43:95-116, 2006.

22. Chien, S.: Mechanical and chemical regulation of endothelial cell polarity. Circulation Res. 98:863-865, 2006.

23. Hornberger, T.A., and Chien, S.: Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle. J. Cell. Biochem. 97:1207-1216, 2006.

24. Wang, Y.; Jin, G.; Miao, H.; Li, J. Y.-S.; Usami, S., and Chien, S.: Integrins regulate VE-cadherin and catenins: Dependence of this regulation on Src, but not on Ras. Proc. Nat. Acad. Sci., USA, 103:1774-1779, 2006.

25. Chen, C.N.: Li, Y.-S. J.; Yeh, Y.T.; Lee, P.-L.; Usami, S.; Chien, S., and Chiu, J.-J: Synergistic roles of platelet-derived growth factor-BB and interleukin-1b in phenotypic modulation of human aortic smooth muscle cell. Proc. Nat. Acad. Sci., USA 103:2665-2670, 2006.

26. Wang, N.; Miao, H.; Li, Y.-S.; Zhang, P.; Haga, J.H.; Hu, Y.; Young, A.; Yuan, S.; Nguyen, P.; Wu, C.-C., and Chien, S.: Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific. Biochem. Biophys. Res. Commun. 341:1244-1251, 2006.

27. Heydarkhan-Hagvall, S.; Chien, S.; Nelander, S.; Li, Y.C.; Yuan, S.; Lao J.; Haga, J.H.; Lian, I.; Nguyen, P.; Risberg, B., and Li, Y.S.: DNA microarray study on gene expression profiles in co-cultured endothelial and smooth muscle cells in response to 4- and 24-h shear stress.  Molec. Cell. Biochem. 281:1-15, 2005.

28. Kaunas, R.; Nguyen, P.; Usami, S., and Chien, S.: ­Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc. Nat. Acad. Sci., 102:15895-15900, 2005.

29. Chiu, J.-J.; Lee, P.-L.; Chang, S.F.; Chen, L.J.; Lin, K.M.; Lee, D.Y.; Hsieh, H.-P.; Usami, S., and Chien, S.: Shear stress regulates gene expression in vascular endothelial cells in response to tumor necrosis factor-alpha. J. Biomed. Sci. 12:481-502, 2005.

30. Li, S; Guan, J.-L., and Chien, S.: Biochemistry and biomechanics of cell motility. Ann. Rev. Biomed. Engineering.  7:105-150, 2005.

31. Li, Y.S.J.; Haga, J.H., and Chien, S.: Molecular basis of the effects of shear stress on vascular endothelial cells. J. Biomech. 38:1949-1971, 2005.

32. Chiu, J.-J.; Chen, L.J.; Chang, S.F.; Lee, P.-L.; Lee, C.-I.; Tsai, M.-C; Lee, D.Y.; Hsieh, H.-P.; Usami, S., and Chien, S.: Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells: Role of NF-kB. Arterioscler. Thromb. Vasc. Biol. I25:963-969, 2005.

33. Wang, Y.; Botvinick, E.L.; Zhao, Y.; Berns, M.; Usami, S.; Tsien, R.Y., and Chien, S.: Visualizing the mechanical activation of Src.  Nature, 434:1040-1045, 2005.

34. Chien, S.; Li, S.; Shiu, Y.T., and Li, Y.S.: Molecular basis of mechanical modulation of endothelial cell migration.  Frontiers in Biosci., 10:985-2000, 2005.

35. Flaim, C.J.; Chien, S., and Bhatia, S.: An extracellular matrix microarray for probing cellular differentiation.  Nature Methods 2:119-125, 2005.

36. Miao, H.; Hu, Y.L.; Shiu, Y.T.; Yuan, S.; Zhao, Y.; Kaunas, R.; Wang, Y.; Jin, G.; Usami, S., and Chien, S.: Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: In-vivo and in-vitro investigations. J. Vasc. Res. 42:77-89, 2005.

37. Liu, Y.; Zhu Y.; Rannou F.; Lee T.S.; Formentin K.; Zeng L.; Yuan X.; Wang N.; Chien S.; Forman B.M.; Shyy J.Y.: Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells. Circulation.110:1128-1133, 2004.

38. Shiu, Y.T.; Li, S.; Marganski, W.A.; Usami, S.; Schwartz, M.A.; Wang, Y.-L.; Dembo, M., and Chien, S.: Rho GTPase mediates the shear-enhancement of endothelial cell migration speed. Biophys. J., 86:2558-2665, 2004.

39. Wang, Y.; Chang, J.; Li, Y.-C.; Li, Y.-S.; Shyy, J.Y.-J., and Chien, S.: Shear stress and VEGF regulate IKK via the Flk-1/Cbl/Akt signaling pathway.  Am. J. Physiol.:Heart & Circ. Physiol. 286:H685-H692, 2004.

40. Chiu, J.-J.; Lee, P.-L.; Chen, C.-N.; Lee, C.-I.; Chang, S.F.; Chen, L.J.; Lien, S.C.; Ko, Y.-C.; Usami, S., and Chien, S.: Shear stress increases ICAM-1 and decreases VCAM-1 expressions induced by tumor necrosis factor-a in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 24:73-79, 2004.

41. Sun, D.; Wang, J.; Yao, W.; Gu, L.; Wen, Z., and Chien, S.:  Tumorigenesis of murine erythroleukemia cell line transfected with exogenous p53 geneClinical Hemorheology and Microcirculation  30:117-126, 2004.

42. Choi, J.; Zhao, Y.; Zhang, D.; Chien, S., and Lo, Y.-H.: Patterned fluorescent particles as nanoprobes for investigation of molecular interactions.  Nanoletters, 3:995-1000, 2003.

43. Zhou, R.H.; Lee, T.S.; Tsou, T.H.; Rannou, F.; Li, Y.H.; Chien, S., and Shyy, J.Y.J: Stent implantation activates Akt in the vessel wall: Role of mechanical stretch in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 23:2015-2020 2003.

44. Chiu, J.-J.; Chen, C.-N.; Lee, P.-L.; Yang, C.T.; Chuang, H.S.; Chien, S., and Usami, S.:  Analysis of the effect of disturbed flow and adhesion molecules in monocytic interaction with endothelial cells. J. Biomech. 36:1883-1895, 2003.

45. Li, S.; Moon, J.; Miao, H.; Jin, G.; Chen, B.P.C.; Yuan, S.; Hu, Y.; Usami, S., and Chien, S.: Signal transduction in matrix contraction and the migration of vascular smooth muscle cells in three-dimensional matrix. J. Vasc. Res 40:378-388, 2003.

46. Zeng, L.; Zhang, Y.; Chien, S.; Liu X., and Shyy, J. Y-J.: Deacetylation of p53 by laminar flow: The role in p21Waf1 regulation.  J. Biol. Chem. 278:24594-24599, 2003.

47. Lin, T.; Zeng, L.; Liu, Y.; DeFea, K.; Schwartz, M.A.; Chien, S., and Shyy, J.Y.J:  Rho activation of sterol regulatory element binding proteins.  Circulation Res. 92:1296-1304, 2003.

48. Chien, S.: Molecular and mechanical bases of focal lipid accumulation in arterial wall.  Progr. Biophys. Molec. Biol. 83:131-151, 2003.

49. Chiu, J.-J., Chen, L.-J., Lee, P.-L., Lee, C.-I., Lo, L.-W., Usami, S., and Chien, S.: Shear stress inhibits the adhesion molecule expressions in vascular endothelial cells induced by co-culture with smooth muscle cells.  Blood, 101:2667-2674, 2003.

50. Li S, Lao J, Chen BP, Li YS, Zhao Y, Chu J, Chen KD, Tsou TC, Peck K, Chien S. Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix. FASEB J. 2003 Jan;17(1):97-9.

51. Labrador V, Chen KD, Li YS, Muller S, Stoltz JF, Chien S. Interactions of mechanotransduction pathways. Biorheology. 2003;40(1-3):47-52.

52. Tzima E, Del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, Schwartz MA. Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J. 2002 Dec 16;21(24):6791-800.

53. Chiu JJ, Chen LJ, Lee PL, Lee CI, Lo LW, Usami S, Chien S. Shear Stress Inhibits the Adhesion Molecule Expressions in Vascular Endothelial Cells Induced by Co-Culture with Smooth Muscle Cells. Blood. 2002 Dec 5 [epub ahead of print]

54. Hu YL, Li S, Miao H, Tsou TC, Del Pozo MA, Chien S. Roles of Microtubule Dynamics and Small GTPase Rac in Endothelial Cell Migration and Lamellipodium Formation under Flow. J Vasc Res. 2002 Nov-Dec;39(6):465-76.

55. Shyy JY, Chien S. Role of integrins in endothelial mechanosensing of shear stress. Circ Res. 2002 Nov 1;91(9):769-75.

56. Zhao Y, Chen BP, Miao H, Yuan S, Li YS, Hu Y, Rocke DM, Chien S. Improved significance test for DNA microarray data: temporal effects of shear stress on endothelial genes. Physiol Genomics. 2002 Dec 26;12(1):1-11.

57. Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S. Interplay between integrins and FLK-1 in shear stress-induced signaling. Am J Physiol Cell Physiol. 2002 Nov;283(5):C1540-7.

58. Weyts FA, Li YS, van Leeuwen J, Weinans H, Chien S. ERK activation and alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts. J Cell Biochem. 2002;87(1):85-92.

59. Yajima N, Masuda M, Miyazaki M, Nakajima N, Chien S, Shyy JY. Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. J Vasc Surg. 2002 Aug;36(2):379-85.

60. Katsumi A, Milanini J, Kiosses WB, del Pozo MA, Kaunas R, Chien S, Hahn KM, Schwartz MA. Effects of cell tension on the small GTPase Rac. J Cell Biol. 2002 Jul 8;158(1):153-64.

61. Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S. Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci. 2002 May 15;115(Pt 10):2199-206.

62. Sotoudeh M, Li YS, Yajima N, Chang CC, Tsou TC, Wang Y, Usami S, Ratcliffe A, Chien S, Shyy JY. Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1709-16.

63. Miao H, Yuan S, Wang Y, Tsygankov A, Chien S. “Role of Cbl in Shear-Activation of PI 3-Kinase and JNK in Endothelial Cells.” Biochem Biophys Res Commun. 2002 Apr 12;292(4):892-9. 2:

64. Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S. “The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells.” Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3546-51.

65. Liu Y, Chen BP, Lu M, Zhu Y, Stemerman MB, Chien S, Shyy JY. “Shear stress activation of SREBP1 in endothelial cells is mediated by integrins.” Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):76-81.

66. Butler PJ, Tsou TC, Li JY, Usami S, Chien S. “Rate sensitivity of shear-induced changes in the lateral diffusion of endothelial cell membrane lipids: a role for membrane perturbation in shear-induced MAPK activation.” FASEB J. 2002 Feb;16(2):216-8.

67. Chen BP, Li YS, Zhao Y, Chen KD, Li S, Lao J, Yuan S, Shyy JY, Chien S. “DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress.” Physiol Genomics. 2001 Oct 10;7(1):55-63.

68. Tzima E, del Pozo MA, Shattil SJ, Chien S, Schwartz MA. “Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment.” EMBO J. 2001 Sep 3;20(17):4639-47.

69. Fisher AB, Chien S, Barakat AI, Nerem RM. “Endothelial cellular response to altered shear stress.” Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L529-33. Review.

70. Hsu PP, Li S, Li YS, Usami S, Ratcliffe A, Wang X, Chien S. “Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation.” Biochem Biophys Res Commun. 2001 Jul 20;285(3):751-9.

71. Zhu Y, Liao H, Wang N, Ma KS, Verna LK, Shyy JY, Chien S, Stemerman MB. ”LDL-activated p38 in endothelial cells is mediated by Ras.” Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1159-64.

72. Wu CH, Lin CS, Hung JS, Wu CJ, Lo PH, Jin G, Shyy YJ, Mao SJ, Chien S. “Inhibition of neointimal formation in porcine coronary artery by a Ras mutant.” J Surg Res. 2001 Jul;99(1):100-6.

73. Zhao Y, Chien S, Skalak R, Lipowsky HH. “Leukocyte rolling in rat mesentery venules: distribution of adhesion bonds and the effects of cytoactive agents.” Ann Biomed Eng. 2001 May;29(5):360-72.

74. Li S, Bhatia S, Hu YL, Shiu YT, Li YS, Usami S, Chien S.” Effects of morphological patterning on endothelial cell migration.” Biorheology. 2001;38(2-3):101-8.

75. Kelemen C, Chien S, Artmann GM. “Temperature transition of human hemoglobin at body temperature: effects of calcium.” Biophys J. 2001 Jun;80(6):2622-30.

76. Butler PJ, Norwich G, Weinbaum S, Chien S. “Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity.” Am J Physiol Cell Physiol. 2001 Apr;280(4):C962-9.

77. Zhao Y, Chien S, Weinbaum S. “Dynamic contact forces on leukocyte microvilli and their penetration of the endothelial glycocalyx.” Biophys J. 2001 Mar;80(3):1124-40.

78. Moore MM, Goldman J, Patel AR, Chien S, Liu SQ. “Role of tensile stress and strain in the induction of cell death in experimental vein grafts.” J Biomech. 2001 Mar;34(3):289-97.

79. Jalali S, del Pozo MA, Chen K, Miao H, Li Y, Schwartz MA, Shyy JY, Chien S. “Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands.” Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1042-6.

80. Lin, K.; Hsu, P.P.; Chen, B.P.; Yuan, S.; Usami, S.; Shyy, J.Y.J., and Chien, S.: Molecular Mechanism of Endothelial Growth Arrest by Laminar Shear Stress. Proc. Nat. Acad. Sci. U.S.A., 97:9385-9389, 2000.

81. Jin, G.; Wu, C.H.; Li, Y.H.; Hu, Y.L.; Shyy, J.Y.J., and Chien, S.: Effects of Active and Negative Mutants of Ras on Rat Arterial Neointima Formation. J. Surg. Res., 94:124-132, 2000.

82. Chen, K-D.; Li, Y-S.; Kim, M.; Li, S.; Chien, S., and Shyy, J. Y-J.: Mechanotransduction in response to shear stress: roles of receptor tyrosine kinases, integrins, and Shc. J. Biol. Chem., 274:18393-18400, 1999.

83. Hu, Y.L.; Li, S.; Shyy, J.Y.J., and Chien, S.: Sustained JNK activation induces endothelial apoptosis: Studies with colchicine and shear stress. Am. J. Physiol. (Heart and Circ.), 277:H1593-H1599, 1999.

84. Li, S.; Chen, P-C. B.; Azuma, N.; Hu, Y-L.; Wu, Z. S.; Sumpio, B. E.; Shyy, J. Y-J., and Chien, S.: Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. J. Clin. Invest., 103:1141-1150, 1999.

85. Chien. S., Li, S., and Shyy, J.Y.J.:  Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension 31 (Part 2):162-169, 1998. (Review)

86. Jalali, S.; Li, Y.-S.; Sotoudeh, M.; Yuan, S.; Li, S.; Chien, S., and Shyy, J. Y-J.: Shear stress activates p60src-Ras-MAPK signaling pathways in endothelial cells. Arterio. Thromb. Vasc. Biol., 18:227-234, 1998.

87. Bhullar, I. S.; Li, Y.-S.; Miao, H.; Zandi, E.; Kim, M.; Shyy, J. Y-J., and Chien, S.: Fluid shear stress activation of IkB kinase is integrin-dependent. J. Biol. Chem., 273:30544-30549, 1998.

88. Li, S.; Kim, M.; Schlaepfer, D.D.; Hunter, T.; Chien, S., and Shyy, J. Y.-J.: Fluid shear stress activation of focal adhesion kinase - Linking to mitogen-activated protein kinases. J. Biol. Chem., 272:30455- 30622, 1997.

89. Lin, M.C.; Almus-Jacobs, F.; Chen, H.-H.; Parry, G.C.N.; Mackman, N.; Shyy, J. Y.-J., and Chien, S.: Shear stress induction of tissue factor gene expression and phosphorylation of Sp1. J. Clin. Invest., 99:737-744, 1997.

90. Hu, Y.L., and Chien, S.: Effects of shear stress on protein kinase C distribution in endothelial cells. J. Histo. Cytochem., 45:237-249, 1997.

91. Shyy, J.Y.J., and Chien, S.: Role of integrins in cellular responses to mechanical stress and adhesion. Curr. Opin. Cell Biol., 9:707-713, 1997. (Review)

92. Li, Y.S.; Shyy, J.Y.J.; Li, S.; Lee, J.D.; Su, B.; Karin, M., and Chien, S.: The Ras/JNK pathway is involved in shear-induced gene expression. Mol. Cell. Biol., 16:5947-5954, 1996.

93. Shyy, Y.J.,  Li, Y.S.;, Lin, M.C., Gregersen, H.,  Chen, W., Yuan, S.,  Almus, F.,  Usami, S. and Chien, S.:  The shear stress-mediated gene expression and the cis-elements involved. J. Biomechanics 28:1451-1457, 1995. (Review)

94. Shyy, Y.J.; Hsieh, H.J.; Usami, S., and Chien, S.: Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium. Proc. Nat. Acad. Sci. U.S.A., 91:4678-4682, 1994.